The drug treatment of staphylococcal prostatitis is based on penicillin, cephalosporin and quinolone antibiotics, and bacterial culture and drug sensitivity test examination are recommended. Prostatitis is a common infectious lesion of the genitourinary system, mainly divided into acute bacterial prostatitis, chronic bacterial prostatitis, chronic non-bacterial prostatitis and other types. Staphylococcus is one of the common pathogenic microorganisms. After the onset of the disease, patients may experience urinary tract irritation symptoms such as frequent urination, urgency, and painful urination, and may experience discomfort such as pain in the perineal region. After the patient’s visit to the clinic, routine prostate fluid examination, bacterial culture and drug sensitivity test are usually required. After diagnosis of staphylococcal prostatitis, antibiotic drugs such as penicillins (ampicillin, penicillin, methicillin, etc.), cephalosporins (ceftriaxone, cefoperazone, cefuroxime, etc.), quinolones (ciprofloxacin, ofloxacin, levofloxacin, etc.) can be chosen for treatment. Staphylococcal prostatitis patients need to go to the hospital in time, improve the examination under the guidance of the doctor’s treatment, the drug should be applied under the guidance of the doctor.