Alternatives to hydrochlorothiazide include spironolactone, furosemide, and others. Hydrochlorothiazide works as a diuretic, which is clinically used in the treatment of hypertension and edematous diseases, and the alternative drugs include spironolactone, furosemide and so on. Spironolactone belongs to the potassium-preserving diuretic, in the diuretic drainage at the same time, can reduce the discharge of potassium in the body, at the same time can inhibit the aldosterone in the body, the main indications for hypertension, heart failure, especially suitable for aldosteronism caused by the treatment of hypertension patients. The adverse reactions of the drug include male breast development, female breast swelling and pain, decreased sexual function, hair growth, etc. It is forbidden for patients who are allergic to the drug components or hyperkalemia. Furosemide is a labeled diuretic, diuretic effect is relatively strong, diuretic at the same time with the role of potassium excretion, the adverse effects of the drug are weakness, thirst, tinnitus, nausea, vomiting, etc., patients allergic to the components of the drug are prohibited. When hydrochlorothiazide is replaced by spironolactone or furosemide, it is important to use the drug under the guidance of a physician to avoid blindly using the drug on your own.