Hepatitis B virus has three antigenic components: surface antigen (HBsAg), core antigen (HBcAg) and e antigen (HBeAg). These three antigens in the body can cause the body’s immune response, producing the corresponding three antibodies, namely anti- HBs, anti- HBc and anti- HBe. These antigens and antibodies can be used as diagnostic markers of hepatitis B virus infection. However, it is difficult to detect the hepatitis B virus core antigen (HBcAg) in the serum by general methods, and only five indicators of surface antigen (HBsAg) and anti- HBs, e antigen (HBeAg) and anti- HBe, anti- HBc can be detected, which is what we usually call hepatitis B five items or hepatitis B two to half. Among these five items, if the surface antigen (HBsAg), e antigen (HBeAg) and anti- HBc indicators are positive, it is often referred to as hepatitis B “major triple-positive” infection, if the surface antigen (HBsAg), anti- HBe, anti- HBc three positive, it is often referred to as hepatitis B “minor triple-positive” infection. If you are positive for surface antigen (HBsAg), anti- HBe and anti- HBc, you are often referred to as hepatitis B “minor triple-positive” infections.