How should post abortion infertility be treated

The patient was infertile for 5 years after abortion, and was infertile after IVF-ET for tubal patency, and then conceived naturally.1. Clinical diagnosis and treatment: The patient, Jiang Mou, 28 years old, was initially seen in May 2004, complaining of infertility for 5 years after abortion. The patient was married in 2000 and had an abortion in May 2000 after 50 days of unplanned pregnancy, with contraception for half a year after the operation, and had been infertile without contraception for the past 5 years. Menstruation was 3-5 days/28-30 days with moderate menstrual flow and no dysmenorrhea. 1, physical examination T: 36.5 ℃, P: 76 beats / min, R: 18 beats / min, BP: 110/70 mm Hg. general condition is OK, clear, spirit is OK, heart and lungs (-), abdominal softness, liver and spleen are not found; gynecological examination: vulva development is normal, vagina is smooth, cervix is smooth, uterus body is normal size, anterior position, activity is poor, and there is no obvious abnormality in double adnexa area. Basic endocrine: FSH: 6.3mIU/ml, LH: 5.60mIU/ml, PRL: 15.8ng/ml, T: 0.3nmol/l, E2: 153.51pmol/l, hysterosalpingography suggests that the uterine cavity is normal in morphology, and bilateral tubes are open, and her husband’s semen test suggests that it is normal. IVF-ET was requested, and a long protocol was used to promote ovulation, with treprostinil 0.1mg, subcutaneous injection, once every other day, on the 3rd day of menstruation, it was changed to 0.05mg injected once a day until the day of HCG injection, and Goonafen 150IU was injected intramuscularly once a day starting from the 3rd day of menstruation, and on the 8th day of menstruation, vaginal ultrasound showed that: endometrium was 0.6cm thick, triple-linear; the right follicle was 1.3cm2 1.2cm2, 1.1cm1; left follicle: 1.2cm3,1.0cm2. She was given 15 IU of urotensin for 3 consecutive days, and ultrasound examination again: endometrial thickness: 0.8cm, type A, right follicle: 1.8cm2, 1.6cm2, 1.4cm1; left follicle: 1.7cm2, 1.6cm2, 1.5cm2, and was given 10,000IU of HCG for intramuscular injection, and her eggs were retrieved on Nov. 3, 2004, and she was given 9 eggs, with 6 embryos. On November 3, 2004, 9 eggs were retrieved and 6 embryos were obtained. Luteal support was started on the day of egg retrieval and 2 embryos were transferred under the guidance of abdominal ultrasound on the 2nd day after egg retrieval, and the transfer went smoothly. The remaining embryos were frozen and preserved, and the luteal support was continued after the transfer. 14 days after the transfer, urine HCG was negative, and blood β-HCG was 2.3 mIU/ml, suggesting that the patient was infertile. The patient was told to rest for 3 months, and after 3 months, frozen embryo transfer was performed. 3 months later, the patient’s menstrual period did not arrive for 10 days, and she came to the hospital to check urine HCG positivity, and blood β-HCG13522.3mIU/ml, suggesting that she was infertile. Ultrasound on 50 days of menopause suggested early intrauterine pregnancy, single fetus, visible buds and fetal heartbeat. Regular antenatal checkups were performed, and a baby boy was delivered at 39+3 weeks of gestation, weighing 3450 grams with normal development. 2.Discussion The patient underwent one abortion after marriage, considering the secondary inflammation of fallopian tube after abortion, which caused the fallopian tube to pass but not smooth, affecting the function of the fallopian tube, resulting in low fertility, coupled with the patient’s mental stress, infertility in the past 5 years. It is reported that about 5% of infertility is caused by mental tension. When humans are mentally stressed, the body undergoes an emergency response with an increase in the release of adrenaline and norepinephrine, an increase in the concentration of catecholamines, an increase in endorphins synthesized by the hypothalamus and pituitary gland, and an increase in the release of prolactin (PRL). All these hormonal changes affect the regulation of the normal menstrual cycle, inhibit the secretion of gonadotropin-releasing hormone (GnRH) and the pituitary response to GnRH, and interfere with the synthesis of ovarian sex hormones, the result of which leads to infertility due to ovulatory disorders. The use of IVF-ET after the stimulation cycle of infertility, and then in the process of waiting for the transfer of frozen embryos natural fertilization, indicating that the tubal insufficiency has a certain compensatory function, and in the process of waiting for the transfer of frozen embryos to release the mental tension, and thus natural fertilization. In addition to the poor function of the fallopian tube, this patient also has mental tension and anxiety factors exist in young, the treatment process should be done patiently counseling, soothing, relieving mental tension and other anxiety. Because of the short period of infertility, ovarian function is good, the choice of drugs for conservative treatment may also be conceived, to give full opportunity to try to conceive, to avoid the waste of medical resources.