Does the cerebrospinal fluid of tuberculous meningitis change?

In patients with tuberculous meningitis, cerebrospinal fluid pressure may appear elevated and clear in appearance. In some patients, the cerebrospinal fluid may be yellowish or have a gross glassy change, and a fibrous film may appear after a few hours of sitting, facilitating the diagnosis of tuberculous meningitis. In addition, cerebrospinal fluid cytology may show an increased cell count. Biochemical examination of the cerebrospinal fluid may show increased cerebrospinal fluid protein and decreased sugar and chloride. Currently, sequencing of Mycobacterium tuberculosis genes in the cerebrospinal fluid can provide additional opportunities for detection.