There are two cases of mixing the first and second injections of the new coronavirus vaccine: one is mixing different types of vaccine products, and the other is mixing vaccines of the same type of vaccine products from different manufacturers; the first case cannot be mixed, but the second one can. First of all, according to the “Technical Guidelines for Vaccination against New Coronavirus (First Edition)” issued by the State Council of China, it is recommended to choose the same type of vaccine product to complete vaccination in the same immunization program, and it is not recommended to mix different types of vaccine products. Different types of vaccines have different immune mechanisms of action, and mixing injections may affect the protective effect of the vaccine. Secondly, when vaccines of the same type and from the same manufacturer are not normally available or when vaccinators are unable to choose vaccines from the same manufacturer for vaccination due to school or work and other reasons, they can choose vaccines from other manufacturers of the same type for vaccination. Vaccinators can change the place of vaccination and try to choose the same type of vaccine from the same manufacturer for vaccination. After consulting with the vaccination office, wait for a better time to receive the vaccine within the recommended vaccination time.