The common cause of toothache is bacterial infection causing pulpitis, apical tooth infection and periodontitis, etc. Due to the inflammatory reaction, the pressure in the pulp cavity increases and causes pain. The drugs used to treat toothache are mainly anti-inflammatory drugs and painkillers, mainly including penicillins, cephalosporins, macrocyclic lipids and non-steroidal anti-inflammatory drugs, not only three. 1, penicillins: such as amoxicillin dispersible tablets, amoxicillin belongs to the penicillin class of broad-spectrum antibiotics, most toothache is caused by bacterial infection, during toothache you can take oral amoxicillin, which has a certain effect on anti-inflammation and pain relief. Mainly for the treatment of Staphylococcus aureus and streptococcal infections; 2, cephalosporins: some patients with penicillin drugs will produce drug allergic reactions, can use cephalosporins, common cephalosporins are cefixime, cefaclor, ceftriaxone, cefoperazone sodium, etc., to the anti-inflammatory effect, but also has a certain analgesic effect; 3, macrolides: if patients are allergic to penicillin drugs and If patients are allergic to both penicillins and cephalosporins, they can choose macrolipids, such as roxithromycin tablets, which is a broad-spectrum antibacterial drug and also has a certain effect on the treatment of toothache; 4, non-steroidal anti-inflammatory drugs: when the toothache is more serious and not easily relieved, choose gaucamycin hydrobromide tablets, which are used to treat toothache caused by anaerobic bacterial infection and can be combined with amoxicillin dispersible tablets and metronidazole tablets. When toothache symptoms are not severe, you can use the above anti-inflammatory drugs and painkillers for relief. However, in the case of acute pulpitis and periapical inflammation, which are characterized by persistent and severe pain, oral anti-inflammatory drugs and painkillers alone have no obvious effect, even if oral drugs with strong analgesic effect are not effective. In this case, early pulpal drainage is required to relieve the pain.