Both metronidazole and tinidazole belong to the nitroimidazole class of drugs, but metronidazole was developed relatively early and belongs to the first generation of nitroimidazole drugs, while tinidazole is the second generation of nitroimidazole drugs that emerged from further research based on metronidazole. The effect of tinidazole is stronger than that of metronidazole, and the side effects are smaller than those of metronidazole. Tinidazole is also more expensive than metronidazole, so patients can choose for themselves, which anti-inflammatory drug to apply for tooth pain. It should also be noted that taking anti-inflammatory drugs for toothache is not a cure, and patients are advised to go to a professional dentist to treat the cause of the toothache.