Sleeping Beauty Syndrome, scientifically known as Klein-Levin Syndrome, or KLS for short, or commonly known as Sleeping Beauty Disease, is a rare neurological abnormality. The main characteristic is sleepiness, the patient will sleep for weeks, or even months, during the slumber, except for their own wake up to eat, drink, anything can not wake up. After the period of slumber has passed, the patient does not remember anything that happened during this period. Many patients report that they lose focus on everything and are very sensitive to sound and light. Some of the female patients become depressed. 1. Introduction The so-called Sleeping Beauty Syndrome, originally named Kleine-Levine Syndrome (KLS for short), is a disorder in which excessive sleep and behavioral changes occur repeatedly. The onset of the disease often sleeps or sleeps most of the day and night, and only wakes up when going to the bathroom and eating. Even when awake, the person’s demeanor may change and they may remain in a trance or childlike state of mind. They may also experience confusion, disorientation, and a general feeling of lethargy or emotional indifference. Patients are often unable to attend school or work due to their episodes. Most people spend almost all day in bed, tired or even unable to communicate with others. 2. Symptoms Most patients describe an inability to focus on everything, and are particularly sensitive to sound and light. The incidence of the disease in adolescents is 1 in 1 million, with approximately 70% of patients being male. For some patients, the disease can sometimes appear asymptomatic for weeks, months or even years, and then relapse because of small warning signs. For those who develop the disease, their health reports are usually unremarkable, but the disease disappears spontaneously after about 8 to 12 years. The cause of this disease remains unclear, and some researchers suspect autoimmune, inferior optic thalamus dysfunction in the brain. The cause of the disease is not known, but is thought to be related to abnormal function of the areas of the brain that control sleep and appetite. 4. Rare There are no more than 1,000 patients worldwide who suffer from this condition. In each case, patients can live a normal life for several weeks or months, during which their sleep patterns and energy levels are normal. But be careful when it’s their turn to sleep and rest. They can sleep for days or weeks at a time. 5. Prevention Doctors can only combine stimulants and sleep medications to prevent patients from falling asleep without warning on the one hand, and to improve the quality of their sleep on the other. 6, global cases The Royal Society Journal once revealed a historical record, recounting the late 17th century, an extremely sleepy man named Samuel Hilton. This male “sleeping beauty” initially began to sleep on May 13, 1694, and did not wake up until a week later. And on April 9, 1695, Hilton fell into a deep and prolonged sleep. Doctors were called in to treat him with bloodletting and fire to no avail. After 17 weeks, Hilton did not wake up until August 7. In 2010, the media announced that the British girl Louisa Bowery was diagnosed with Klebsiella. Bowery was diagnosed with Klein-Levin syndrome. She could sleep for 22 hours a day, up to 12 days at a time. According to her mother, she developed this drowsiness after recovering from a flu in 2008. “She was acting sleepy and never got better. She could fall asleep in school classes and mumbled something under her breath that no one else could understand, as if she was talking in her sleep.” In November 2012, the media reported that Nicole DeLeon, a 17-year-old girl in the United States, had been diagnosed with a “sleepy” condition. DeLeon was diagnosed with “Klein-Levine syndrome,” in which she sleeps for 18-19 hours a day. The most amazing record is that she slept from Thanksgiving until January of the following year, 64 days, setting a record for the longest personal lethargy. Nicole’s mother, Vicki, said her daughter had to sleep 18 to 19 hours a day, and even if she woke up to eat, she was “sleepwalking and wouldn’t remember what she had done”.