Overview of intracranial infection Intracranial infection is one of the more serious diseases of the central nervous system and a common postoperative complication in neurosurgery clinics. In neurosurgery, physicians sometimes need to treat patients through some invasive operations, and this is when pathogens such as bacteria, viruses, parasites, mycoplasma, chlamydia, mycobacteria, rickettsia and other pathogens have an opportunity to invade the central nervous system and cause intracranial infections, resulting in a series of symptoms. Symptoms of intracranial infection The symptoms of intracranial infection are mostly fever, general malaise, drowsiness, limb pain, etc. In severe cases, patients may have convulsions, aphasia, mental abnormalities, mental retardation, hemiplegia, or even coma. Other patients may present with headache, vomiting, cervical tonicity and meningeal irritation signs. In severe cases or in patients with delayed treatment, death may occur from massive brain parenchymal infection, inflammatory brain edema, or even brainstem infection. Diagnosis of intracranial infection How can you tell if you have an intracranial infection? This involves the diagnostic criteria of intracranial infection: 1. clinical signs and symptoms of intracranial infection such as high fever, headache, neck tonicity; 2. cerebrospinal fluid examination with white blood cells WBC>0.01X109/L, with increased multinucleated cells predominant. Sugar <2.25mmol/L, chloride <120mmol>0.45g/L; 3. Positive results of cerebrospinal fluid bacterial culture; 4. A definite cause of infection, such as cerebrospinal fluid leakage, etc. Anyone who has the 3rd article can confirm the diagnosis, such as a negative bacterial culture of cerebrospinal fluid needs to be integrated with the rest of the articles. How to treat intracranial infections Intracranial infections are more difficult to treat because of the presence of the blood-brain barrier, and it is difficult for general drugs to reach the intracranial area to play a role; especially many patients develop drug-resistant bacterial infections (such as Klebsiella pneumoniae infection, Acinetobacter baumannii infection, etc.) due to improper disposal or delayed treatment, and for these, conventional anti-infection treatment is even more helpless. At this point, it is particularly important to find a correct treatment method.