There is no clinical statement on what medication is most effective for premature ejaculation. Usually patients with premature ejaculation can take medication such as Dapoxetine as prescribed by the doctor. A variety of factors can cause premature ejaculation in men, such as unpleasant sexual experiences, hormone level abnormalities, and so on. Because premature ejaculation is easy on the patient’s physical and mental health, so the patient can follow the doctor’s instructions to use medication, clinical common treatment drugs are dapoxetine and other 5 hydroxytryptamine reuptake inhibitors. Some patients with premature ejaculation can also take doxazosin, terazosin and other α-adrenergic blocking agents to reduce sympathetic tension, delay ejaculation, etc., and follow the doctor’s instructions for the rational application of tramadol on the treatment of premature ejaculation also has a certain role. For those who are not satisfied with the effect of medication, they can also be treated by surgery such as dorsal penile nerve selective cutting. It is recommended that patients with premature ejaculation be treated with medication under the guidance of a doctor, and not to use medication indiscriminately or increase or decrease the dosage of medication on their own, so as to achieve the desired therapeutic effect.