Patients with bronchiectasis are prone to combined Pseudomonas aeruginosa infections, which are naturally resistant to certain antibiotics. Therefore, for patients with bronchiectasis, the following major classes of antibiotics should be used: i. Broad-spectrum penicillins, including meloxicillin, piperacillin, and sulbactam. Second, certain third-generation cephalosporins, such as ceftazidime, cefoperazone, sulbactam; fourth-generation cephalosporins such as cefepime. Third, quinolones, you can use levofloxacin, ciprofloxacin, and moxifloxacin for Pseudomonas aeruginosa is relatively poor. Aminoglycosides, such as amikacin, have better efficacy for Pseudomonas aeruginosa, but bronchiectasis combined with Pseudomonas aeruginosa infection, it is not recommended to apply amikacin alone for treatment. Fifth, monocyclic β-lactams, such as aminoglutethimide for Pseudomonas aeruginosa also has a certain degree of efficacy. Sixth, carbapenems, such as imipenem, meropenem, etc.