Not every pregnant woman over the age of 35 must undergo non-invasive DNA screening, but it is recommended to do so. Therefore, non-invasive DNA prenatal testing can be chosen after assessment by a prenatal diagnostician. However, for some ultra advanced maternal age, i.e. maternal age ≥ 38 years and spouse age ≥ 45 years, other chromosomal abnormalities may occur in addition to trisomy 21, 18 and 13, and for these abnormalities, the detection rate of non-invasive DNA is very limited and there is a risk of missed screening. Therefore, the suitability of non-invasive DNA for advanced maternal age as a method of prenatal screening requires a professional prenatal diagnostic The doctor fully evaluates and still recommends performing amniocentesis if there is a risk of fetal chromosomes. If the pregnant woman and her spouse are still young, have no adverse pregnancy history, no other high-risk factors, or if the pregnant woman is of advanced age but has a risk of miscarriage and there are contraindications for amniocentesis, noninvasive DNA testing can be considered. If the noninvasive DNA test shows a high risk, indicating the possibility of fetal chromosomal abnormalities, further amniocentesis is still recommended to clarify whether there are fetal chromosomal abnormalities.