Mycobacterial infections in men have symptoms. Typical symptoms are urethral tingling, which may be accompanied by urinary frequency, urinary urgency, urinary pain and other urethral irritation, and some patients may have urethral mucous or purulent discharge. Male mycobacterial infection is relatively rare, common causes are sexual partner infection, the use of immunosuppressants after organ transplantation, resulting in lower body resistance, long-term chronic wasting diseases, etc., the use of spectrum antibiotics resulting in dysbiosis, low body resistance after treatment of malignant tumors, and other cases. After the condition is clear, it is recommended that formal examination, through the culture of urethral secretions and drug sensitivity test, to find the causative bacteria, targeted treatment, the whole treatment until cure, it is best to treat both husband and wife together, can ensure the treatment effect and reduce the recurrence.