Nephritis with leg swelling can be treated by applying diuretics, commonly used drugs include furosemide, torasemide, etc. Long-term therapeutic drugs may also be applied such as valsartan, benadryl, or even hormones (prednisone) or immunosuppressants (cyclophosphamide). Leg swelling caused by nephritis is mainly caused by a large amount of urinary protein leading to hypoproteinemia. At this time, short-term swelling can be reduced by applying diuretics, such as furosemide, torasemide and so on. Long-term should also actively treat the primary pathology, such as the application of sartans and prilosec drugs, such as valsartan, benazepril, chlorosartan potassium, etc., for the lowering of urinary protein and antihypertensive treatment; depending on the type of pathology, glucocorticoids or other immunosuppressive agents may also be applied, such as prednisone acetate, tacrolimus, cyclophosphamide, cyclosporine and so on. Diuretics may lead to serious electrolyte disorders, elevated blood lipids, etc. Hormones and immunosuppressive agents may lead to serious infections, bone marrow suppression, etc. Therefore, the above drugs need to be applied under the guidance of nephrologists, and should not be applied blindly on their own, so as to avoid adverse effects. Nephritis patients are recommended to consult regular hospitals and standardize treatment under the guidance of physicians.