At present, with the improvement of people’s living standards, in the premise of gradually improving material life, people began to pursue the satisfaction of spiritual and emotional life. Couples have a harmonious and satisfactory sex life is an essential condition for family life. However, due to the high pace of modern life, high pressure, more couples are affected by all kinds of sexual dysfunction, sexual life is not satisfied or disharmony, resulting in a crisis between couples abound. Premature ejaculation is one of the common sexual dysfunctions. Premature ejaculation is currently classified into four types: primary premature ejaculation, acquired premature ejaculation, variant premature ejaculation and premature ejaculation-like ejaculatory dysfunction (which should be distinguished by a doctor). At present, the treatment of premature ejaculation is mainly through behavioral therapy and medication. Behavioral treatment I know is mainly through the insertion of the technique of moving and stopping during intercourse (i.e., stopping pumping before ejaculation, taking deep breaths, making the muscles of the lower abdomen and perineum fully relaxed, and controlling the ejaculatory reflex), and repeated training to obtain the ability to control ejaculation. Of course, it is difficult to obtain efficacy through behavioral therapy alone, because it is also very difficult, even painful, for any normal male to control ejaculation by behavioral therapy alone, so necessary medication-assisted treatment is essential. The medications highlighted in the American Urological Association’s guidelines for the treatment of premature ejaculation are SSRIs, or antidepressants. The antidepressants that have better efficacy and less side effects in the treatment of premature ejaculation are sertraline (trade name: Zoloft), paroxetine (Seroquel) and tincture of duloxetine (Symbicta). Taking these drugs for premature ejaculation is generally preceded by taking one tablet daily for two months. When not having intercourse, it is recommended to take one tablet daily after or during dinner (such as Cymbalta); if you are planning to have intercourse today, it is best to take it 4-6 hours before intercourse. After two months, change to as-needed, i.e. take 1-2 tablets only 4-6 hours before each intercourse and not when you do not have intercourse. All antidepressants will have some adverse reactions during the course of taking them, mainly some mental side effects, such as weakness, drowsiness, abdominal distension, loss of appetite, etc., but they are generally mild and usually diminish or disappear after 4-5 days, and most people can tolerate them. Antidepressants should be used in the treatment of premature ejaculation as individualized treatment, such as most people can get good results by taking the regular daily dose, but some people may not feel good to delay the ejaculation time, and at the same time there are no obvious side effects, this may be the regular dose failed to show good results, consider increasing the dose, such as after two weeks of taking the drug can gradually increase to 2 tablets per day, after two months For example, after two weeks of taking the drug, the dosage can be gradually increased to 2 tablets per day, and after two months, 1-2 tablets before each intercourse; for some people, the effect of delaying ejaculation is obvious after taking the regular dosage, but at the same time, they feel that the side effects are greater, which means that the dosage may be too large, and the dosage should be reduced appropriately, such as changing to half a tablet per day within two months, and after two months, half to 1 tablet before each intercourse. During the treatment process, many people ask about the duration of treatment, i.e. whether it needs to be taken for life. I believe that, like learning to drive, you should exercise your ability to control ejaculation during intercourse and gradually stop taking the medication when you are satisfied with your ability to control ejaculation. However, the duration of training and the course of medication needed to assist each person is different. This process should not be rushed, as speed is not enough and needs to be done gradually. Usually 3-4 months is necessary. At this time, patience is needed and close cooperation with the doctor and timely feedback of the treatment to the doctor to be able to get timely guidance. These are some common problems in the treatment of premature ejaculation and some precautions in the process of taking medication, I hope they can be of some help to the majority of friends. Sincerely hope that all friends suffering from premature ejaculation can obtain satisfactory results, have a beautiful and happy sex life, and make our contribution to the development of a harmonious society.