In spite of the great improvement of cardiac surgery technology and the use of preoperative antibiotics, mediastinal infection is still a serious complication with an incidence of 0.6-2.65% and a mortality rate of up to 40%. Treatment of mediastinal infection 155 cases, by comparing in several aspects, we concluded that the medial muscle flap docking method is effective in the treatment of mediastinal infection after cardiac surgery. General data From January 2008 to March 2014, 155 patients with mediastinal infection complicated by cardiac surgery (coronary artery bypass grafting and heart valve replacement, respectively) were admitted to the Aviation General Hospital. We used the medial myocardial flap docking method and the lateral myocardial flap reversal method for the treatment of mediastinal infection, respectively, and there were no significant differences between the two groups in terms of age, sex, length of history of mediastinal infection, degree of infection, type of primary surgery and general information of causative organisms. In contrast, the medial muscle flap docking method was less than the lateral muscle flap reversal method in terms of operative time, intraoperative bleeding, postoperative drainage, postoperative tube time and hospital stay, and the difference was significant. The medial muscle flap docking method has the following advantages: 1, the medial pectoralis major muscle is free on both sides at the sternum and the 1st-6th ribs through the fascial gap to form a muscle flap, and the free range is based on the standard of no tension during docking suture, so the operation time is significantly shortened as well as the intraoperative bleeding is significantly reduced; 2, both sides of the pectoralis major muscle are docked and sutured at the midline, which not only plays a role in compressing the free wound to stop bleeding but also eliminates the muscle gap and reduce the possibility of fluid accumulation, the postoperative drainage is less, so the postoperative chest drainage tube is removed and recovered earlier, significantly shortening the number of hospital days; 3, during violent coughing, the sternum bears an instantaneous pulling force of about 150 kg; and the removal of the intraoperative wire causes postoperative instability of the sternum; therefore, the docking suture of both pectoralis major muscles limits the movement of the sternum, and the recovery of sternal stability can reduce the the chance of mediastinal infection and improve the cure rate;4. Pain and destruction of thoracic stability can lead to restricted respiratory dynamics, shallow and fast breathing and reduced alveolar ventilation, patients are afraid to cough and retain sputum, thus causing pulmonary infection; in addition, the chest wall appears to be paradoxically breathing, which can make the pressure on both sides of the chest unbalanced, the mediastinum moves with breathing, affecting blood return and causing arrhythmia.5. Postoperative chest wound is flat and beautiful. There is no local augmentation after turning the muscle flap. In conclusion, compared with the method of disconnecting the lateral pectoralis major muscle flap and turning it over to fill in the suture, the free medial pectoralis major muscle flap docking to fill in the suture has the advantages of less damage to the body, simpler operation, less bleeding, faster recovery and less complications, etc. It is a preferred treatment method for patients with postoperative mediastinal infection.