Repeated friction between the skin of male and female genital area and the outside world may cause the genital area to generate tension blisters, and the blisters may gradually subside until they disappear after excluding the stimulating factors. Other common possible causes are fungal bacterial infection, viral infection, epidermal cell loosening, etc.: 1, fungal bacterial infection: daily inattention to personal hygiene can lead to fungal or bacterial infection of male and female genitalia, generating blisters, which may be accompanied by redness and swelling of the genital glans and discharge in men, and increased vaginal discharge and even abnormal leucorrhoea in women; 2, viral infection: common herpes simplex virus may cause blisters on the genitals of both men and women. The male genital blisters are mostly found in the foreskin, glans, coronal groove and other parts of the female genital blisters are mostly found in the labia, clitoris and other parts, perianal, groin, scrotum and other parts of the generation is less common. The walls of the blisters are thin, the bottom of the blisters are red, they are prone to ulceration, and the ulcerated parts may become erosion leading to pain and itching. It is usually crusty and self-healing, and may be accompanied by fever, fatigue, headache and other symptoms; 3. Epidermal cell release: Vulvar aspergillosis caused by epidermal cell release is common in the female genitalia. The disease is mostly caused by genetic factors and commonly manifests as blisters on erythematous or normal skin. The surface of the blisters is flaccid and easily broken, and when they break, they become ulcerated and may become infected with a foul odor. Severe cases may lead to infection of the female genital mucosa and even to hypoproteinemia.