Medications for the treatment of severe cold and headache include non-steroidal anti-inflammatory, anti-viral and elimination of bacterial infections. When patients feel unwell, they should seek medical attention and be treated under the diagnosis of a doctor. 1. Non-steroidal anti-inflammatory drugs: If the cold is caused by poor self-care, patients are advised to follow the doctor’s instructions to relieve the severe headache caused by the cold through the use of non-steroidal anti-inflammatory drugs such as ibuprofen delayed-release capsules, compounded acetaminophen tablets, indomethacin enteric-coated tablets and other medications. 2. Antiviral drugs: Colds are mainly viral infections and can be treated symptomatically. If the symptom is serious or definitely influenza virus infection, antiviral drugs, such as oseltamivir phosphate capsule should be used as soon as possible to relieve severe headache caused by cold. 3. Elimination of bacterial infection drugs: If the flu complicates bacterial infection can also cause headache, in addition to symptomatic medication, should be fundamentally anti-infective treatment, such as follow the doctor’s instructions for the use of roxithromycin dispersible tablets, levofloxacin tablets, and other antibiotic drugs to relieve their own discomfort. However, it should be noted that if the headache is particularly serious, you should go to the hospital for examination in a timely manner, and follow the doctor’s instructions under the guidance of the doctor’s medication, in order to restore health as soon as possible.