Elevated aminotransferases due to pharmacologic liver injury usually do not rebound after normalization. Transaminase is one of the most important clinical indicators of normal liver function. There are many reasons for elevated transaminases, including viral infections, cirrhosis, liver cancer, bile duct blockage, drug-related liver injury, cholecystitis, late night, fatigue, alcoholism, etc. Many drugs are converted and metabolized by the liver. Clinically, many drugs are converted and metabolized by the liver, and transaminases will be elevated and liver injury will occur during the period of medication, which can be restored to normal after stopping the medication or using hepatoprotective drugs, and generally will not rebound. It is recommended that patients with drug-induced liver injury should pay attention to a light diet, eat more fresh vegetables and fruits, avoid spicy and stimulating food, avoid smoking, drinking, exertion, staying up late, and review liver function regularly.