As technology advances, genetic screening for deafness is gradually entering people’s lives. Genetic screening for newborn deafness has been introduced as a routine test in hospitals where it is available and in families where it is available or needed. So, what is a gene? How are genes related to deafness? Let’s get to know genes and hear the story of genes! A gene is a structural and functional unit of genetic material within a cell, which exists in the chemical form of deoxyribonucleic acid (DNA) on chromosomes. In humans, genes are passed from parent to offspring through germ cells. The DNA molecule has a double helix model and is self-replicating. A gene is a segment of DNA that has a specific “genetic effect”. It determines the synthesis of RNA, proteins, etc. within the cell, and thus determines the genetic traits of the organism. In the absence of mutations in the nucleotide sequence of a gene, modifications to the gene such as DNA methylation or demethylation, histone acetylation, etc. may also lead to changes in the activity of the gene, resulting in changes in the gene-determined phenotype, which can be transmitted over a few generations. The nature of the gene The chemical nature of the human gene is DNA The basic unit that makes up a DNA molecule is a deoxyribonucleotide. Each deoxyribonucleotide is composed of phosphate, deoxyribose and nitrogenous bases. There are four types of bases: adenine A, guanine G, cytosine C and thymine T. Depending on the base, four different deoxyribonucleotides can be formed. These four deoxyribonucleotides are arranged in a certain order to form a long chain of deoxy polynucleotides – the single strand of DNA. Two adjacent deoxynucleotides are connected by phosphodiester bonds, and the genetic traits of living organisms are stored in the sequence of deoxynucleotide arrangements for genetic information. Thus, the arrangement of deoxyribonucleotides is the core of DNA inheritance. One of the most frequently heard words because of their relevance to disease is: mutations! Why do genes change? How do they change? What are the results? Follow Professor Chen Li and hear the story of genes! I asked the gene, “Every living thing has its own genome, and every genome has a fixed number. The gene replied, yes, there is a fixed number, but the fixed number is variable. I asked, “Why and how do they change? The gene said, “Actually, change is the norm, it is always changing. It just doesn’t leave a reason for each change. If the only way to survive is to leave this change, this change is left behind, and the fixed number will change. This change can be a few dozen more bases. A few dozen per year, for a million years, can be as many bacteria. To stay is acqusition, to stay for a reason, is adaptation. 2. How does the quorum change? The process of change? I asked the gene, can you tell me how you change the definite number? Gene said, there are many kinds of change, each has a different process. First, let’s talk about the change of the fixed number. In specific regions of the genome, there are additions and subtractions of bases. Addition increases the fixed number and subtraction decreases it. As for where to add and where to subtract, you can read the book. I say, okay. Add for C, subtract for T. 3, there is a war between genomes? Genes answer, there is. One thing down one thing, small devour big, big eat small. The smaller ones are more sinister, such as viruses. But the survival of the fittest, passed the test, is the rebirth of the fire, from the virus is not infested. So each individual genome, have the ability to be reborn by fire. And, it can be a different fire. I sighed, the virus is pretty tough! The genes say, yes, that’s evolution. Darwin, if he saw the virus, would have said, phagocytosis, more powerful than eating! 4 .Why should there be two sets of sets? A: For life, one set is enough. For the production, two sets of safety. There will be harm in life, harm in life can be motivating, in production, must be detrimental. This, I agree. Another question, will two sets be used at the same time in life? A, you can use only one set, the need for two sets of cases, maybe there, see please tell! 5, pro, and I talk to you, is from a single cell, or the whole of the cell? A, if I am a bacteria, basically a single cell. If I am a human, and as from a single neuronal cell, so more fair. I think so. So again, the gene that comes from a neuronal cell, you’re changing that too? Also being phagocytosed? Also stay changed? Also bathed in fire? Also stay a set? Answer, think about it and then answer. 6 , how to communicate between genes? A: There is write, there is say, there is remember. Write is transcription, say is a functional protein, there is a record, is the modification, the so-called epistasis. Again, is writing different from remembering? A, it is different, it is a different reaction. Think about it, also right. 7. Do you also have gene groups? A, yes. In the original nucleus, gangs are also called manipulative subopteron. A, co-prosperity and symbiosis. The environment changes quickly, together, can explore, can take, can solve, can use. 8, you genes will also 123? A, the prokaryotic have round, said a relative order. Eukaryotic have body, said a different kind of group. Write sometimes there will be a difference in the amount of relative than, perhaps more important. 9 .You genes can also hide and seek? A, yes, can hide in introns. Another question, the benefits of hiding? A, there is hiding, there is looking. There are combinations, different combinations. One can then be two and three. Lao Tzu has said, one will be two, two will be three, three will be all things. The hiding of the true nucleus is the birth of change. I thought that this could be nonsense. Genes say, rip is important. 10, genes how to make mistakes, know mistakes, correct mistakes? A, making mistakes is the norm, copying will be wrong, writing, speaking, remembering the process will be wrong. Knowing the process of error, because there is a template, a comparison, know that there are problems, to change. And the result of correcting mistakes are two, stay wrong, go wrong. If the wrong is less than the thing, in fact, it does not matter right or wrong, live to change, it is good. 11, gene, ah, can you tell me a story of your rebirth in fire? The story of the protagonists and supporting characters, they will face what kind of disaster, will have what kind of choice, there are how to step out of the predicament? Gene repeatedly said, “Have you tried? Dream? 12, gene change: the result of change, can be molecules become larger, can be molecules become smaller, can be not too big or small, but the content has changed. In short, there are three different consequences of G+,G- and Gx. What is the motive for the change? It can be the heaven and earth species. It is common knowledge that the sky is a ray and changes under X-ray. The universe is active and the game between the stars has an effect on the genes. The earth, is the food chain formed between the various creatures on the ground. To escape, to eat, there will also be change. What about the species, reproduction. Also therefore, the change of genes, there can be a change in the sky, the earth, the species. Therefore, the genetic variation, there can be sky change molecules, earth change molecules and species change molecules. These three types of molecules can have intersection. One of the most interesting ones is the ground-variable molecule. How many kinds of ground variation are known? To answer this question, it is necessary to understand that for any ground change, there should be an exogenous base molecule present. If the exogenous molecule is a virus, it can be an integrator. If the exogenous source is a monotreme, it is a monotreme enzyme. However, the repair of the sky change, and the homologous recombination of the self change, may also be involved in the process of the ground change. What we are concerned with now is the process of ground change that leads to G+.