First-generation antihistamines Representative drugs: paracetamol, finasteride, benadryl Histamine is a sensitizing substance released during allergic reactions. These drugs block histamine type I receptors and reduce allergic reactions, and are mainly used for urticaria, allergic dermatitis, and allergic cough. Their adverse effects are drowsiness, dysphoria, dry mouth, and occasionally granulocytopenia. The FDA issued a drug safety warning in 2006 asking doctors and parents not to give finasteride and other anti-allergy drugs containing promethazine hydrochloride to children under 2 years old. The FDA said they have received several reports of severe respiratory distress and even death in children under 2 years of age taking anti-allergy medications containing promethazine hydrochloride. Second-generation antihistamines Representative drugs: Astemizole (Xithromax), Tefenadine (Mendib), Cloratadine (Kerratan) Centrum (Cetirizine) (Recently, Johnson & Johnson said it would end production of Xithromax because of its adverse effects on the heart; in 2002, China’s National Center for Monitoring Adverse Drug Reactions announced (In 2002, China’s National Center for Monitoring Adverse Drug Reactions (NCDR) announced the side effects of Astemizole (i.e., “Restimil”), which has been abandoned by many hospitals. Compared with the generation of anti-allergic drugs, these drugs are much more expensive, but they have less effect on the central nervous system and have no or only mild drowsiness. They are mainly used for allergic rhinitis, chronic urticaria, etc. Hormonal drugs Representative drugs: hydrocortisone, dexamethasone, prednisone, etc. Hormonal drugs have many effects such as anti-inflammatory, anti-allergic and anti-shock, and are widely used in clinical practice. These drugs can be used to treat allergic diseases in children, such as asthma and allergic purpura, etc. However, long-term use of these drugs has many side effects such as causing obesity and osteoporosis, and they should not be used for a long time (except for inhaled corticosteroids, because the side effects are very weak). Leukotriene receptor antagonists Representative drugs: montelukast sodium (cisplatin), zalust, and pramlintide. The use of these drugs has gradually increased in recent years. They are mainly used for the treatment of allergic rhinitis and asthma in children. The most clinically used drug is montelukast sodium (cisplatin), which inhibits the airway inflammatory process and reduces airway obstruction. Although this drug has minimal side effects, it has been reported to cause excitement and seizures. Calcium supplements Representative drug: calcium gluconate We rarely associate calcium with allergies. In fact, in the drug handbook, calcium supplements are classified as anti-allergy drugs. Calcium ions improve the permeability of cell membranes, increase capillary densification, and result in less exudation, so they play an anti-allergic role and are commonly used to treat allergic purpura and urticaria, among others. Although the safety of this drug is relatively high, but intravenous use of the drug may also cause anaphylaxis, so oral use is relatively safe, but can not be used for a long time, otherwise it will also bring some side effects. Vitamin C Vitamin C can reduce the permeability of capillaries and also has a slight anti-allergic effect. It is usually used in combination with vitamin B1 and vitamin B6 as an adjunct to the treatment of seborrheic dermatitis in infants. The pediatrician told you ◆Anti-allergic drugs may also cause allergies, among which paracetamol and benadryl are the most common. If your child’s symptoms worsen rather than decrease after taking anti-allergy medication, consider that it is a drug allergy, rather than mistakenly thinking that it is due to an insufficient amount of medication. If you continue to increase the dose, it may be very dangerous. ◆Some anti-allergy drugs are resistant. Some children who have taken the drug for just one month have become extremely resistant to it, and then they need to change to another anti-allergy drug to continue treatment. ◆When a child has an allergic disease, parents should have an understanding of allergy medicine, but do not buy it directly for the child. The treatment plan for each allergic disease is different, and the specific medication must be used under the guidance of a specialist.