Under normal circumstances, you need to go to the hospital at 12 weeks of pregnancy to build a card, also known as the mother and child health care booklet, after building a card to start regular prenatal checkups, the first maternity program is as follows: I. Routine health care content to establish a pregnancy health care booklet; women to determine the week of pregnancy and project the expected date of delivery by asking the doctor; assessment of pregnancy risk factors by the doctor; measurement of blood pressure, weight and body mass index; gynecological examination to clarify the presence of gynecological diseases The fetal heart rate will be detected by Doppler around 12 weeks of gestation. The mandatory tests include routine blood, urine, blood group, fasting blood sugar, liver function, kidney function, hepatitis B, syphilis, HIV, thalassemia, and ultrasound examination during early pregnancy to determine intrauterine pregnancy and gestational week. III. Preparation items HCV screening; anti-D titer testing for Rh-negative individuals; 75g OGTT testing for high-risk women; thyroid function screening; serum ferritin testing for those with hemoglobin <110g/L; cervical cytology for those not tested in the first 12 months of pregnancy; cervical discharge testing for gonococcal and Chlamydia trachomatis; testing for bacterial vaginosis; aneuploidy maternal during early pregnancy Serological screening (10-13) weeks + 6 days; ultrasonography to measure fetal nuchal translucency thickness (11-13) weeks + 6 days of gestation; chorionic villus biopsy (10-13) weeks + 6 days of gestation; electrocardiography. IV. Health education and guidance such as awareness and prevention of miscarriage; nutrition and lifestyle guidance; avoiding exposure to toxic and harmful substances and pets and careful use of drugs; vaccination during pregnancy; changing poor lifestyle; avoiding high-intensity work, high-noise environment and domestic violence; maintaining mental health; supplementing folic acid up to 3 months, and continuing to take multivitamins containing folic acid if available.