Carbamazepine is used as the drug of choice for trigeminal neuralgia. Due to the widespread use of this drug, its adverse effects have become increasingly prominent and are receiving more and more attention. The adverse effects of carbamazepine are dizziness, drowsiness, dry mouth, nausea and vomiting, dyspepsia, change in appetite, abdominal distension and constipation, etc. Most of them are mild and transient, and usually do not require discontinuation. The most common skin damage is eczema, dermatomyositis, exfoliative dermatitis, etc. Once these adverse reactions occur, the drug should be discontinued immediately, and the patient can be cured after using hormones and symptomatic treatment. In the process of treating diseases with carbamazepine, there are reports of heart rhythm disorders, conduction block and heart failure, often due to the damaging effects of drug overdose on the heart. Nystagmus, slurred speech, dyskinesia, vertigo, drowsiness, and confusion caused by carbamazepine have been reported repeatedly. Occasionally, carbamazepine has been reported to cause hematuria, proteinuria, glycosuria and elevated non-protein nitrogen and decreased water excretion, and hyponatremia. Erythromycin can increase the blood concentration of carbamazepine, and even toxic reactions can occur. In addition, there are reports of neurotoxic reactions to carbamazepine induced by isoptin.