Congenital osteogenesis imperfecta is a genetic disorder that is very rare and usually characterized by blue eyes. Due to the defective skeletal growth, the child is usually short, does not grow tall easily, and has fragile bones, just like osteoporosis in the elderly, and is likely to fracture under the slightest violence. The development of the limbs and spine is usually deformed, the spine is not the normal physiological curvature of a person, there is usually scoliosis, the development of the arms and legs mostly have abnormalities such as limb curvature, the teeth are usually stunted and the bones are weak. The treatment of this disease is troublesome, because it is a congenital genetic disease, there is no good treatment to change the genes, the focus of treatment should be on the prevention of fractures in children, according to the physical ability of the child to carry out appropriate daily activities and exercise, training the child’s ability to live independently, in the case of serious deformities can wear orthopedic braces to correct the deformity development. The child’s intelligence and nervous system are generally not impaired, and there is no obstacle to fertility, but attention should be paid to the child’s psychological problems.