Many diseases in dermatology require topical glucocorticoids for treatment. To use this drug properly and reasonably, one needs to understand some knowledge about glucocorticoids. The most common clinical classification of glucocorticosteroids is four levels: superpotent, potent, moderately potent and weakly potent. Super- and strong-acting glucocorticosteroids are indicated for severe, hypertrophic lesions; short-term application, no more than 2 to 3 weeks; should not be used in children under 12 years of age; should not be used over a large area for a long period of time; and should not be used on the face, breast, perineum, or folds. Weak-acting glucocorticosteroids can be used for mild to moderate lesions; can be used on the face and thin and tender skin areas; suitable for long-term use on larger areas. Others apply to medium-acting glucocorticosteroids. Long-term use of glucocorticosteroids should pay attention to the occurrence of local adverse reactions (such as skin atrophy, capillary dilation, swelling lines, hirsutism, acne, bacterial infection, purpura, etc.) and systemic adverse reactions (such as medically induced adrenocortical insufficiency, Cushing’s syndrome, psychoneurological symptoms, glaucoma, cataracts and menstrual disorders, etc.).