Currently, there are several treatment modalities for trigeminal neuralgia, but none of them can achieve a completely ideal approach. That is, each of these treatment modalities has its own strengths and weaknesses as well as different indications. The best results can be achieved by an experienced doctor who can develop a suitable treatment plan for patients with different causes of trigeminal neuralgia. The treatment of trigeminal neuralgia can be roughly categorized into three types of treatment: medication, closed treatment and surgery, in addition to acupuncture, Chinese medicine, physical therapy, massage and other treatment modalities, which have a certain effect on temporary relief of pain. Medication is the preferred treatment option for first-episode trigeminal neuralgia, and is also a necessary screening tool. First-time patients taking medication should actively undergo the necessary tests to exclude secondary trigeminal neuralgia caused by tumors or other factors. The treatment medication is mostly carbamazepine, which is taken at an initial dose of 0.1-0.2g three times a day, and can be increased appropriately if it is not effective. Patients with initial onset of trigeminal neuralgia often achieve significant results after drug treatment, but most patients’ pain control effect will gradually decline after long-term use of drugs, and sooner or later, intolerable adverse drug reactions will occur, and other forms of treatment should be considered at this time. There are several surgical procedures for the treatment of trigeminal neuralgia, including trigeminal nerve peripheral branchotomy, trigeminal nerve hemilaminectomy, trigeminal nerve branch I, II and partial hemilaminectomy, trigeminal nerve posterior rhizotomy, trigeminal nerve microvascular decompression (MVD) and other surgical procedures. These surgical procedures have different symptoms and the best procedure should be selected by experienced specialists according to the patient’s condition. In recent years, the emergence of Gamma Knife makes trigeminal neuralgia patients have an additional choice, Gamma Knife is mostly used for the treatment of primary trigeminal neuralgia, the application of focused gamma radiation irradiation of the trigeminal nerve root into the cerebral bridge area, the recent efficiency of 86%-89%, Gamma Knife treatment of trigeminal neuralgia’s greatest advantage is its safety, mostly in the middle-aged and elderly, the risk of surgery is relatively high, Gamma Knife treatment is often the Gamma knife treatment is often the best choice for such people. Other treatment modalities include radiofrequency electrocoagulation selective destruction of the trigeminal nerve hemimelia, glycerol injection destruction of the posterior root of the trigeminal nerve hemimelia, balloon compression of the trigeminal nerve hemimelia, and avulsion of the peripheral branches of the trigeminal nerve. There are many treatment modalities for trigeminal neuralgia, which can be selected appropriately according to the patient’s condition to obtain better treatment results.