H. pylori is a spiral-shaped, microaerobic bacterium that requires very demanding growth conditions. H. pylori is parasitic in human gastric mucosal tissues, and the prevalence of H. pylori infection in the population is about 40%. H. pylori infection can cause a variety of diseases, including gastritis, peptic ulcers, and gastric cancer. Patients with H. pylori infection usually experience the following symptoms: 1. acid reflux – H. pylori induces a large secretion of gastrin, resulting in excessive stomach acidity, which manifests as acid reflux and heartburn. 2, epigastric pain – due to damage to the stomach and duodenal mucosa, some patients may also experience recurrent episodes of severe abdominal pain, a small amount of bleeding in the upper gastrointestinal tract. 3, bad breath – Helicobacter pylori lives in dental plaque and infection occurs in the oral cavity, which may lead to bad breath, and in severe cases there is often a special oral odor that cannot be removed no matter how much cleaning is done. Helicobacter pylori is one of the most direct germs that cause oral odor. 4, epigastric fullness, discomfort or pain after eating, often accompanied by other adverse symptoms, such as warmth, bloating, acid reflux and loss of appetite. The mode of transmission of H. pylori is not very clear, and the most likely route is oral-oral, fecal-oral transmission. China is one of the countries with high prevalence of H. pylori infection, and as a major cause of chronic gastritis, peptic ulcer and gastric cancer, a feasible measure to treat peptic ulcer and gastritis and prevent gastric cancer is to eradicate H. pylori infection. As most of the patients with early gastric cancer have no symptoms, and even if a few patients have some symptoms, they are non-specific, such as loss of appetite, early satiety, abdominal discomfort, etc., which are easily ignored as peptic ulcer or other gastrointestinal diseases. At present, many medical institutions have made H. pylori screening a routine test, but whether and how to eradicate H. pylori requires gastroenterologists to develop individualized treatment plans according to the specific circumstances of each patient.