This is not a bad thing in itself, at least they are much less anxious and nervous than first-time mothers, but they tend to get “lax”. I sometimes joke with pregnant mothers, “Your second baby can’t talk yet, so I’m going to be upset on their behalf! . Although this is a joke, it is really a heartwarming tip from my heart. (1) Pregnancy care should be regular and good compliance will significantly increase the safety of pregnancy and delivery: due to advanced age or other reasons, the frequency of maternity examinations will increase. At present, medical institutions already have a more systematic and comprehensive prenatal care process, so there will be different targeted examinations for different weeks of pregnancy, and if you miss them, you will lose the best period for haircut maternal-fetal abnormalities. (2) balanced nutrition, proper exercise and reasonable weight gain: this is actually especially important for second pregnancy mothers, because when you want a second baby, pregnant mothers tend to weigh more than when they had their first baby, especially at the beginning of the population policy adjustment period, some women are already older, overweight, or even obese may be. It is well known that being overweight or obese is itself associated with many diseases, such as hypertension, diabetes, and abnormal lipid metabolism. If you gain weight unreasonably during pregnancy, you will be more likely to suffer from pre-eclampsia, gestational diabetes, etc. (3) It is important to choose a health care provider: especially for pregnant mothers with pregnancy complications, it is best to choose a general hospital to facilitate joint treatment and follow-up of the original disease. (4) The chances of pregnancy complications increase with age: for example, hypertensive disorders of pregnancy and gestational diabetes. If you develop serious pregnancy complications during pregnancy, the primary hospital may recommend you to transfer to another hospital or emergency transfer for treatment, which will be good for both the pregnant mother and the born baby. (5) Pregnant mothers with a history of cesarean delivery should have an ultrasound in early pregnancy: to understand the relationship between the fetal sac and the original uterine scar location, except for scar pregnancy. If the fetal sac is attached to the lower part of the uterine cavity and the placenta is in the uterine scar, it increases the risk of placenta praevia and even placental implantation. (6) Increased chance of prenatal diagnosis: Prenatal diagnosis may be recommended if you are of advanced age (note that the age of delivery is defined as 35 years or older), have had a previous baby with abnormalities, or have chromosomal abnormalities in both spouses. Prenatal diagnosis is performed by obtaining fetal cells through different means (including chorionic villus biopsy, amniocentesis, umbilical cord blood puncture, etc.) for genetic diagnosis; in addition, most of the amniotic fluid is derived from fetal urine, so amniotic fluid extraction for testing can also be used for certain metabolic diseases. The first baby is developing normally and the couple is normal, so how can the second baby be abnormal? In fact, fetal developmental abnormalities are absolutely age-related, especially the chance of chromosomal abnormalities. Some pregnant mothers fear the risks of invasive prenatal diagnosis and rely unilaterally on non-invasive fetal DNA testing. When we say non-invasive fetal DNA testing (NIPT for short), it is actually a high-level Down’s screening for almost prenatal diagnosis, which mainly targets screening for 21-3 disorders, but karyotyping is a test that covers all 46 chromosomes. For mothers of advanced age, not only the risk of Down’s syndrome will increase, but also the chance of other chromosomal abnormalities in number as well as structure, which Therefore, it is best to approach the issue of prenatal diagnosis scientifically for mothers with advanced second pregnancies.