Nodular acne is a more serious form of acne that is treated with topical medications, systemic medications and physical therapy. 1. Topical medication: Due to the severe inflammatory reaction of nodular acne, it is often necessary to use topical antibiotic creams as prescribed by the doctor, such as fusidic acid cream, mupirocin cream, etc., which can effectively inhibit the proliferation of Propionibacterium acnes to achieve therapeutic effects. 2. Systemic medication: If the size of nodular acne is relatively large, it is necessary to take oral medication, such as minocycline, doxycycline, and for some patients, isotretinoin capsules, which can effectively relieve the symptoms. 3. Physical therapy: Commonly used methods are phototherapy methods, such as red and blue light treatment, which can reduce the inflammatory response. Nodular acne should go to the hospital, under the guidance of specialists to take targeted treatment. Medications should be used as prescribed by the doctor.