Muscle lysis generally refers to rhabdomyolysis syndrome, the treatment should remove the causative factors such as avoiding strenuous exercise, in addition to rehydration therapy, blood purification therapy when necessary. Rhabdomyolysis syndrome is a clinical syndrome caused by necrosis of rhabdomyoblasts due to trauma, strenuous exercise, drugs, toxins, infections and other etiological factors, which can cause muscle pain, muscle weakness, deepening of the color of the urine, and in severe cases, can lead to acute kidney injury and severe electrolyte disorders. The first step in the treatment of rhabdomyolysis syndrome is to remove the causative factors, such as avoiding strenuous exercise, stopping the use of related drugs such as statin lipid-lowering drugs, and controlling infections. In addition, active rehydration therapy and correction of electrolyte disorders should be carried out. The use of the alkaline drug sodium bicarbonate can also alkalize the urine and prevent or reduce the damage of myoglobin to the renal tubules. If there are already manifestations of acute kidney injury such as oliguria, anuria or the presence of severe hyperkalemia, severe acidosis, etc., blood purification treatment, such as hemodialysis, hemofiltration, etc., should be carried out to maintain life. In conclusion, the appearance of severe muscle pain, dark yellow urine, need to be alert to the possibility of rhabdomyolysis, should seek medical treatment in a timely manner, the use of drugs should be under the guidance of a doctor.