Recently, a 25-year-old male patient was admitted to Ward 3 of our hospital with the diagnosis of meningitis of undetermined nature and possible tuberculosis. The patient had a headache without any obvious cause 8 days ago and became unconscious 1 day ago. On admission, the patient was confused, unconscious, irritable, bilateral pupils were equal in size, about 1.5 mm in diameter, weak response to light, cervical resistance about 4 transverse fingers, coarse breath sounds in both lungs, no rales were heard, cardiac rhythm was uniform, abdomen was distended, abdominal palpation and neurological examination were uncooperative. After admission, he was given anti-TB, dehydration, hepatoprotection, nutrition and other symptomatic supportive treatment. 5 days later, his condition suddenly worsened and he became comatose, with no response to call, corneal inversion, bilateral pupils of unequal size, about 4 mm in diameter on the left and 3.5 mm on the right, weak response to light, and possible brain herniation. He was immediately transferred to the ICU for resuscitation treatment, and lateral ventricular drainage was performed at the same time. On the same day, he developed apnea and was treated with tracheal intubation and mechanical ventilation. The patient was a female, 19 years old. She was admitted to the hospital with “intermittent cough and sputum for 2 months, aggravated by abdominal distension, abdominal pain and diarrhea for 6 days. Diagnosis: acute hematogenous pulmonary tuberculosis in both lungs, coated (no sputum), initial treatment: tuberculosis with multiple plasma cavities, anemia, hypoproteinemia, incomplete intestinal obstruction, electrolyte disorder, drug-related liver damage. After collective discussion in the department, Director Zhao Aibin concluded that the patient’s rapid onset, short course and rapid progress were not entirely consistent with the manifestation of tuberculous meningitis, and the possibility of acute disseminated encephalomyelitis (fulminant) could not be excluded. The patient was resuscitated while provincial experts were consulted to exclude encephalitis B, etc. After active resuscitation and treatment, the patient was successfully extubated after 10 days, and the lateral ventricular drain was removed after 2 weeks, and the patient was discharged after 3 weeks. Acute disseminated encephalomyelitis (fulminant) has a rapid onset, a dangerous condition, and a high mortality rate, with death occurring within a few days after onset. The successful resuscitation of this severe case in the ICU not only reflects the further improvement of our hospital’s diagnosis and treatment level, but also reflects the new progress of our nursing team in the care of severe neurology patients.