Depression after mole spotting is generally a normal phenomenon, most patients will gradually heal to achieve a flat appearance in about 3 to 6 months, and can also be intervened by laser and topical application of drugs and other measures. There will be scabs and scabs off during the healing process after mole spotting, generally there will be a slight depression of light red trauma locally after the scabs fall off, epidermal growth factor can be used as early as possible to promote the growth of cells, which can play a role in nourishing the skin, accelerate the formation of tissue cells and collagen, in order to achieve the purpose of improving the depression. Fractional laser can stimulate subcutaneous collagen regeneration and rearrangement, and stimulate the initiation of the skin’s damage re-repair mechanism to improve localized depressions. It can also be injected into the subcutaneous by a new type of medical aesthetic means PRP, which injects autologous platelets with high concentration into the subcutaneous, which is rich in stimulating factors that can act locally to promote the repair and proliferation of the fibrous tissues under the subcutaneous. Patients who have depression after mole spotting and are willing to be treated can go to regular hospitals for consultation and reasonable treatment according to specialized medical advice.