Psoriasis, also known as psoriasis in clinical practice, is an immune-mediated, chronic, recurrent, inflammatory, systemic disease induced by a combination of genetic and environmental effects. At present, there is no drug that can cure psoriasis, according to the patient’s specific situation, we need to choose topical drugs, oral drugs, biological agents and other drugs to relieve the condition. 1. Topical drugs: moisturizers are usually used to strengthen the protection of the skin barrier. Topical drugs such as vitamin A acid drugs, vitamin D3 derivatives (carbotriol or tacalcitol), calcium-regulated phosphatase inhibitors have obvious efficacy, but also a variety of keratin contributing agents (tar preparations, salicylic acid ointment, etc.). 2. Systemic drugs: immunosuppressants are mainly used in the treatment of moderate to severe plaque-type, erythrodermic, pustular and arthropathic psoriasis, commonly used methotrexate, cyclosporine, etc.; retinoic acid drugs are mainly used in the treatment of plaque-type, pustular and erythrodermic psoriasis; antibiotic drugs should be used in patients with obvious infections or pan-emergent pustular psoriasis. 3. Biologics: (Targeted immunomodulators) Biologics are indicated for patients with moderate to severe psoriasis and/or psoriatic arthritis for whom conventional systemic therapy is ineffective or poorly tolerated. They include monoclonal antibodies for receptors such as TNF-alpha, IL-12/23, and IL-17A. Psoriasis is currently no drug can cure, patients need to consult the doctor in time, under the guidance of the doctor to use drugs, do not use on their own, so as not to delay the condition.