Spider nevus on the palm of the hand may be related to physiological factors such as increased estrogen during puberty and pathologic factors such as viral hepatitis and cirrhosis of the liver. Spider nevus is a vascular nevus formed by the expansion of the terminal branches of small arteries in the skin, which is composed of a central artery and many tiny blood vessels radiating outward, i.e., tiny blood vessels extending outward, collectively referred to as spider’s foot (pseudo-foot), which is named spider nevus because of its resemblance to a spider. 1. Physiological factors: Adolescent girls in the peak growth and development period, the body secretion of a large number of estrogen and the production of a large number of estrogen during pregnancy, can appear spider nevus. 2. Pathological factors: hepatitis, liver cirrhosis, liver cancer, rheumatism, rheumatoid arthritis, Cushing’s syndrome, vitamin B deficiency, coloring dry skin disease, systemic lupus erythematosus and other diseases can lead to the rise of estrogen in the body, the emergence of spider nevus of the head, neck, upper chest, upper limbs and other parts. Spider nevus on the palm of the hand is recommended to consult a doctor in time for a clear diagnosis and targeted treatment under the guidance of the doctor.