Objective: Advanced age is a risk factor for perioperative mortality in CABG surgery, and with the advent of an aging society, more and more elderly patients are undergoing CABG surgery. In this paper, we summarize the clinical data of elderly CABG patients older than 80 years old, and analyze and discuss the surgical approach and perioperative management. Methods: Patients with CABG performed from September 2013 to September 2014 in the cardiovascular surgery departments of the two hospitals were selected as the study population, and senior patients older than 80 years old were selected to summarize the clinical data. Results: A total of 27 patients met the criteria, 18 males and 9 females. Age was 80-86 y, 81.26±1.68 y. Weight was 57-90 kg, mean 64.19±9.08 kg. including 3 cases of stable angina, 19 cases of unstable angina, and 5 cases of myocardial infarction. The EF was 42%-70%, mean 62.12±5.69. The internal mammary artery and the saphenous vein were used as bridging materials, the internal mammary artery was used as the anterior descending branch, and the saphenous vein was used as the bridging material for the rest. The number of bridging vessels was 2-6, with an average of 3.86±0.97 bridges. Postoperative hemostasis was strictly enforced, and platelets and cold precipitation were administered according to the clotting time and thromboelastography index. Dopamine, norepinephrine, nitroglycerin and other active drugs were routinely given postoperatively, and epinephrine, milrinone, levosimendan and other active drugs were given to critically ill patients. Intraoperative erythrocyte suspension infusion was 0-5 units with a mean of 2.57±1.86 units, and 7 patients operated without blood. The postoperative drainage was 423.88±171.37 ml at 24 hours. the operation time was 217.78±50.33 min, the first postoperative ventilator-assisted breathing time was 962.78±268.64 min, two patients were intubated twice, and one patient was intubated three times. The postoperative ICU time was 2.71±2.44 days. 26 patients were discharged with recovery and 1 patient died, with a mortality rate of 3.7%. Among all patients, there were 2 cases of preoperative IABP, 5 cases of postoperative pulmonary infection, 3 cases of respiratory failure, 2 cases of renal failure with 24-hour blood purification, and 1 case of sternal fracture and secondary surgery. Conclusion: 1. Age is no longer a contraindication to coronary artery bypass surgery, and CABG is used as much as possible for patients of advanced age. The non-extracorporeal cardiac nonstop operation is used, and IABP is given to assist if necessary, and then extracorporeal circulation is given to assist completion in patients who really cannot maintain hemodynamic stability. 2. Remove the tracheal intubation as early as possible, perform respiratory function exercise, and give non-invasive ventilation to improve lung function if necessary. Get out of bed early for rehabilitation training to prevent deep vein thrombosis. 3. Pay attention to postoperative nutritional therapy, give gastric motility drugs and oral nutrition solution after extubation, and give enteral nutrition by gastric tube if necessary. Keywords:80 years old, non-stop bypass, clinical experience.