Headache and bitter mouth are two symptoms, headache is usually caused by neurological diseases, bitter mouth is mostly caused by digestive system diseases, but if the two symptoms appear at the same time, in Western medicine, it is more likely to be caused by cold, in Chinese medicine, it is more likely to be caused by exuberant liver fire. 1. cold: most of the cold is caused by viral infection, which will increase the inflammatory secretions of the body and make the nerves stimulated, thus triggering headache. At the same time, the virus will invade the patient’s mouth, nasal cavity, etc., appearing dry mouth, bitter mouth, nasal congestion, runny nose and other symptoms. At this time, the first thing is to actively treat the cold. Generally, after the cold is cured, the symptoms of headache and bitter mouth will gradually disappear. 2. Liver fire: This performance can also be seen in the theory of Chinese medicine that the liver fire is strong and the blood of the whole body will surge to the head, so that the blood perfusion of the brain increases and headache symptoms appear. Because the liver and gallbladder are connected, if the liver is not good, the gallbladder may also be damaged and bile secretion will be affected, resulting in the feeling of bitterness in the mouth. If the headache and bitterness persist without relief, it is recommended to go to the local hospital in time to improve the CT or MRI of the head, cerebral hemogram, liver and gallbladder ultrasound and other examinations to clarify the specific cause and then provide targeted treatment.