Chronic brucellosis is mainly treated with antibiotics, commonly used drugs include doxycycline, streptomycin, rifampicin, etc. Different medication regimens are formulated according to the patient’s condition. 1. 6 weeks with doxycycline combined with gentamicin or streptomycin, rifampicin, for patients with uncomplicated infection. 2. If the patient is combined with spondylitis, sacroiliac arthritis, etc., doxycycline can be used in combination with gentamicin and rifampicin. Doxycycline and rifampicin should be used for at least 3 months and gentamicin for 1 week. 3. If there is a combination of meningitis, etc., treat with doxycycline and rifampicin for 5 months, combined with ceftriaxone for 1 month. Patients who have chills and fever, sweating, generalized pain, headache and other symptoms are recommended to consult a doctor for timely treatment, standardized treatment under the guidance of the doctor, and follow the doctor’s instructions to take medication.