Patients presenting with chest tightness and constant urge to sigh are more commonly seen in patients with depression in clinical practice. Patients with depression can come to the clinic with complaints of chest tightness, panic, shortness of breath, and alas, sighing mainly. Patients with depression tend to have low mood, slow thinking, and reduced volitional activity, accompanied by low self-evaluation, self-guilt and self-blame. Patients often feel a lack of interest, fun, no meaning to live, so there are self-injurious thoughts or behavior. At this point, if it is said to affect social and occupational functions such as work and study, depression can be diagnosed, and clinical treatment requires systematic antidepressant therapy, such as the application of 5-hydroxytryptamine reuptake inhibitors such as paroxetine, sertraline, fluoxetine, etc., with good results in the whole course of treatment. In addition, physical therapy can be used transcranial magnetic stimulation and electroconvulsive therapy to achieve good therapeutic results.