Higher levels of bile acids in pregnant women are often seen in intrahepatic cholestasis in pregnancy, which can usually be treated with hepatoprotective drugs combined with drugs to improve appetite loss. Hepatoprotective drugs 1, ursodeoxycholic acid as the treatment of intrahepatic cholestasis in pregnancy as a first-line drugs, can significantly improve the biochemical indicators and symptoms; 2, S-adenosylmethionine as a second-line drugs or joint therapy drugs, also has the effect of hepatoprotection, can be taken orally or intravenously. Second, improve the loss of appetite drug high bile acid can lead to liver function obstruction, will be accompanied by loss of appetite, malnutrition, abdominal fluid and other adverse symptoms, need to cooperate with the nutritional agents for joint drug therapy, in order to alleviate and improve the adverse symptomatic reactions, available multivitamin tablets, hyaluronidase, coenzyme B12 and so on to alleviate. The cause of intrahepatic cholestasis in pregnancy is still unclear, mostly related to female hormones, genetics, immunity and other factors. It is necessary to pay attention to the professional doctor’s guidance for the rational use of medication.