Chest tightness, palpitations, shortness of breath are non-specific symptoms, mostly seen in cardiac diseases, respiratory diseases and neuropsychiatric diseases, as follows: 1. Cardiac diseases require careful history taking, physical examination and ancillary examinations, mostly considering arrhythmias, coronary artery disease and heart failure, with ancillary examinations including ECG, cardiac ultrasound and blood biochemical tests. Electrocardiogram can often suggest many important information, including myocardial ischemia, acute myocardial infarction, arrhythmia, hypertension causing non-specific ST-T changes. BNP biochemical examination is important to identify cardiac disease and respiratory system induced shortness of breath, if BNP <100ng/L, then cardiac causes of chest tightness and shortness of breath can be excluded; 2. Respiratory system diseases, chest X-ray or chest CT, further if necessary bronchoscopy. At the same time, chest X-ray and chest CT are also important for the diagnosis of heart-related diseases, which can reveal the presence of heart enlargement, pericardial effusion and pleural effusion; 3, hyperventilation syndrome, which causes obvious discomfort after emotional excitement, such patients need to be given appropriate comfort and soothe their emotions, and the situation can gradually improve. If the patient has chest tightness, palpitation and shortness of breath after overexcitation, ECG or blood gas analysis should also be done to clarify whether there is respiratory alkalosis. Therefore, it is advisable to pay high attention to patients with chest tightness, palpitation and shortness of breath, and perform ECG, chest X-ray, chest CT and cardiac ultrasound if necessary, as well as to comfort the patients and perform blood gas analysis if necessary for further clarification.