Erythromycin does not treat urinary tract infections, which are mostly caused by gram-negative bacilli, such as Escherichia coli or Klebsiella, but also by mycoplasma, chlamydia, and gonococcus. Erythromycin is not effective in treating these infections, and symptomatic treatment with cephalosporins or quinolones or macrolides is recommended. Erythromycin is more effective in treating gram-positive cocci and is often indicated for infections of the epidermis or skin areas, such as the appearance of prepuce, glansitis or vulvar inflammation, which can be treated topically with erythromycin. However, in case of full urinary tract infections, it is recommended to select specific drugs for treatment based on the results of the culture. These need to be decided by relevant laboratory tests at the hospital. If erythromycin is used hastily or for a long time for treatment, it can even lead to local fungal growth or medications that are not appropriate, leading to prolongation of the disease and increasing the patient’s pain.