Blood nevus of hepatocellular carcinoma is commonly known as spider nevus, which is characterized by branching dilatation of the end of small skin arteries and shaped like a spider. When chronic cirrhosis is combined with liver cancer patients, spider nevus can appear; most of them appear above the torso, especially on the face, neck and palms of hands. Spider nevus in liver cancer patients is caused by decreased ability of liver to remove estrogen, resulting in increased estrogen and insufficient synthesis of androgen in the body. It shows red spider-like shape, and when the center point is pressed with cotton swab and tongue depressor, the whole vascular nevus can be seen disappearing; after removing the pressure, blood fills up again from the center to the periphery. According to the characteristics of liver blood return, spider nevus distribution is more in the region of superior vena cava. That is, neck, face, upper forearm, bilateral shoulder, upper arm and back of hand and dorsal side of fingers. Spider nevus of liver cancer should be treated under doctor’s guidance firstly; if the size and number of spider nevus increase significantly in a short period of time, it may suggest that the condition is aggravated, and one should go to regular hospitals in time and standardize the treatment, so as to avoid delaying the condition.