Many patients and some physicians in dermatology clinics describe allergies as being caused by immune deficiency, which is false. Allergic reactions, or hypersensitivity reactions, are also often referred to as allergic reactions. It is an immune response in which the organism is stimulated by certain antigens, resulting in physiological dysfunction or tissue cell damage. It is generally classified into four types, but also into six or more. Immunity refers to the immune function, or immune response. It refers to the whole process of recognition and removal of antigens by the immune system; it includes both intrinsic and adaptive immunity. Allergic reactions can occur when the following problems occur in the immune function; 1. The response is too strong or lasts too long in the immune defense. 2. Breakdown of immune tolerance in immune self-stabilization. 3.Disruption of immune regulation in the immune self-stabilization function. We often talk about allergic reactions, generally referring to type 1 allergic reactions also called tachyphylaxis, which are produced by specific IgE antibody-mediated, with obvious individual differences and genetic predisposition. Allergic diseases are a series of pathological reactions caused by the organism’s hypersensitivity to external substances, which are actually pathological immune relative enhancement!