Botox injections are indicated for early wrinkles, while injections for severe wrinkles in older people are also effective but less so. This treatment cannot improve wrinkles caused by skin aging or sun damage, nor can it improve skin laxity because these wrinkles are not caused by excessive contraction of facial muscles, so Botox local injections cannot completely replace facial surgery to remove wrinkles; although Botox is not teratogenic, it is best not to use it for pregnant and lactating women; it is prohibited for those with ptosis; it is prohibited for those with neuromuscular diseases such as myasthenia gravis and multiple sclerosis; it is prohibited for those with severe cardiac, hepatic, and hepatic diseases. The drug is not suitable for patients with blood disorders and children under 1 or 2 years old; it is not suitable for people with fever and acute infectious diseases; it is not suitable for very thin people because the muscles are too thin and can easily diffuse into the surrounding muscles after injection, resulting in adverse reactions; it is not suitable for people who are allergic to albumin or botulinum toxin and people with allergies. Botulinum toxin injection for wrinkle removal should not be used for people with unstable mental state or unrealistic expectation of treatment effect.