Enlarged lymph nodes in the neck are seen for many reasons. For enlarged lymph nodes caused by inflammation and local infection, oral anti-inflammatory medications can be taken, choosing cefadroxil tablets or roxithromycin dispersible tablets. In case of enlarged lymph node infection in the neck caused by tuberculosis, systematic anti-tuberculosis treatment should be given with commonly used drugs such as rifampin, remifentan, ethambutol and pyrazinamide. During the treatment period, attention should be paid to monitor the changes of liver function indexes, because TB drugs have some adverse side effects, and liver-protective treatment such as oral liver protection tablets or hepatocyte can be taken. In addition, patients with malignant tumors have metastasis of lymph nodes in the neck, and the fusion of lymph nodes will also cause pain, in which case surgery is not suitable, but pain relief treatment can be chosen. Commonly used are opioid receptor antagonists, choose aminoglutethimide tablets or tramadol hydrochloride tablets, and morphine tablets can also be applied at a later stage.