There are several causes of blistering in the upper jaw, and it depends on the specific situation. The common cause of blistering in the upper jaw is apical tooth infection, where tooth decay is not treated in time and bacteria further infect the “dental nerve” (i.e., the dental pulp), and the inflammation of the dental pulp is not effectively treated, which can break through the gums and drain pus outward, forming small pus pockets in the upper jaw. This often requires root canal treatment to relieve the tooth. Blistering in the upper jaw can also be a blood blister formed after local trauma, usually caused by choking with hard objects while eating, or caused by burns, which is usually self-absorbing and does not require treatment, and can be treated by a doctor when the blister is large in scope to avoid pain and infection after breaking. Blisters on the palate may also be localized cysts or tumors, which may manifest as larger lesions with a longer duration, and some patients have symptoms related to lesion growth, pain, bleeding, and pus flow, which require further clinical examination and, if necessary, early surgical removal. Blistering of the palate may also be caused by a viral infection or a large vesicular mucosal disease of its own. In short, blistering of the palate is not a specific disease, but a symptom that manifests itself in the mucosa of the palate and requires a professional judgment by the dentist according to the specific situation.