Bipolar disorder, also known as manic-depressive disorder, belongs to bipolar disorder and is characterized by abnormally high or low emotion, including mania and depression in two manifestations. The different states of bipolar disorder in girls have different performance. The manic state can be manifested as high mood, fast thinking transformation, high energy, etc., while the depressive state can be manifested as low mood, slow thinking, behavior inhibition, etc. Girls will experience more depressive episodes compared to boys, and symptoms can also appear in a rapid cycle. A. Manic state:1. High mood: Mostly manifested as happy spirit, good self-perception and abnormally pleasant mood. Some patients may also show irritability and excitement; 2. Rapid change of thinking: mostly manifested as self-conscious quick thinking, words cannot keep up with the speed of thinking, attention is easily shifted with the environment, ideas drift, often suddenly changing topics; 3. High energy: full of interest in all things, activities obviously increase, active participation in new things, but often unable to complete effectively. When the disease is severe, there may be a loss of self-control and rude behavior; 4, other: because of the patient’s high energy, it can lead to excessive physical exertion, leading to weight loss, sleep reduction and other symptoms. Second, depressive state:1, depressed mood: mainly manifested as often pessimistic mood, depression, depression, despair, some patients can also appear anxiety, easily agitated, serious cases may be painful; 2, slow thinking: often appear slow reaction, closed thinking, thinking ability, memory loss, etc., can often lead to active speech reduction, slow speech, learning difficulties, serious cases can not complete communication with others; 3. Behavioral inhibition: mental indifference, indifference to things, reluctance to interact with others, and in serious cases, it can be manifested as not moving, not speaking, not eating, etc.; 4. Other: symptoms such as panic, fatigue, sleep disorder, loss of appetite, weight loss, and abdominal pain, diarrhea, anorexia, stomach discomfort, etc. may also appear. Bipolar disorder generally has an episodic course, manic and depressive states can alternate, and some patients can be self-limiting and can be relieved by themselves without special treatment, but the recurrence rate is high. Girls with suspected symptoms should actively consult a doctor and, if necessary, use medication under the guidance of a doctor, such as mood stabilizers, anti-psychotic drugs, antidepressants, and physical therapy, etc. Effective psychotherapy and intervention are also very important, such as cognitive-behavioral therapy and family therapy, etc. Family members should try to create a harmonious family environment for patients with bipolar disorder, and communicate and guide more.