The appearance of spider nevus does not necessarily mean that the liver disease is serious, it is recommended to carry out standardized examination under the guidance of the doctor, according to the examination results to determine the progress of the disease. Spider nevus is a mass of arteries on the skin similar to spider’s legs. Generally speaking, the rise of estrogen level will lead to the appearance of spider nevus, because the rise of estrogen level will stimulate blood vessels to secrete vasculogenic growth factors, resulting in the growth of skin capillary mass manifesting spider nevus. In female pregnancy and puberty, endocrine exuberance, when the body estrogen content increases the appearance of spider nevus, this situation does not mean that the liver disease is serious. If liver function decreases, such as in hepatitis B patients, the amount of estrogen metabolized by the liver is inactivated, and the estrogen content in the body increases, resulting in the appearance of spider naevi, which is indicative of severe liver disease. The appearance of spider nevus does not necessarily indicate serious liver disease, it is recommended to do further examination under the guidance of a doctor to clarify the cause of the disease and provide systematic and regular treatment.