Drugs to reduce fasting blood glucose include insulin, biguanide, sulfonylurea, etc., such as: metformin, glimepiride, etc. It is recommended to follow the doctor’s instructions to take medication. 1. Insulin: Insulin can inhibit hepatic glycogenolysis and gluconeogenesis, and reduce hepatic output of glucose. It promotes hepatic uptake of glucose and synthesis of hepatic glycogen. Promote the extraction of glucose and amino acids from muscle and adipose tissue, and promote the synthesis and storage of protein and fat. 2. Metformin: e.g. Metformin, its mechanism is to reduce hepatic glucose output and improve peripheral insulin resistance. 3. Sulfonylureas: such as glimepiride, which stimulates insulin secretion from pancreatic β-cells and increases the ability of insulin to bind to target tissues. If fasting blood glucose is high, you should go to the hospital in time, do not self-medicate, in order to avoid delay or adverse reactions.